UROTHERAPY FOR PATIENTS WITH CANCER

                              Joseph Eldor, MD

                          Theoretical Medicine Institute
                     P.O.Box 12142, Jerusalem, 91120,Israel
                     E-mail: a1b2c3d4@netvision.net.il

          Subcutaneous urine injections was practiced in 1912 by
          Duncan (1) from New York under the name of auto-pyotherapy
          for urinary infections, and in 1919 by Wildbolz (1) from
          Bern for diagnostic purposes. Cimino (2) from Palermo
          reported in 1927 on the use of auto uro-therapy for urinary
          infections. Rabinowitch (3) in 1931 described this
          auto-urine therapy for gonarthritis. Jausion et al. (4)
          used this kind of therapy in 1933 for desensitization and
          endocrinological problems. They treated with auto urotherapy
          injections patients who suffered from migraine, pruritus,
          asthma, urticaria, eczema, psoriasis, etc. Day (5)in 1936
          treated patients with acute and subacute glomerulonephritis
          by injection of an autogenous urinary extract. Sandweiss,
          Saltzstein and Farbman (6) reported in 1938 that an extract
          from urine of pregnant women has a prophylactic and
          therapeutic effect on experimental ulcers in dogs. Shortly
          thereafter the same group noted that an extract from urine
          of normal women has a similar beneficial effect (7).
          In 1926 Seiffert first described the construction of ileal
          loop conduits for urinary diversion (8). Bricker in the
          1950s popularized the use of the ileal loop as a means of
          supravesical urinary diversion following exenteration for
          pelvic malignancy in adults (9). Ureterosigmoidostomy as a
          means of urinary diversion was used widely from 1920 to
          1955. It was this type of implant which Hammer first
          reported in 1929 associated with tumor (10).
          Peyer`s patches are immunocompetent lymphoid organs which
          participate in intestinal immune responses (11). Epithelial
          cells within the crypts of the small bowel are one of the
          fastest dividing cells in the body and yet they show one of
          the lowest rate of malignant transformation (12). Stem cells
          in the mucosa of the small bowel can divide every 8 to 12
          hours (13). Tapper and Folkman (14) demonstrated that
          exposure of intestinal segments to urine causes marked
          lymphoid depletion in the segments. These studies give
          additional support to the idea that a lymphocyte suppressive
          factor exist in urine (15). The continued presence of urine
          bathing the intestinal mucosa appears to locally inhibit
          regeneration of the Peyer`s patches.
          Starkey et al. (16) detected in human urine a material that
          is biologically and immunologically similar to epidermal
          growth factor that causes proliferation and keratinization
          of epidermal tissues.
          The increased susceptibility of the colon to cancer
          associated with the existence of an implanted ureter has
          been theorized to relate to 3 factore: 1. The role of the
          urine in the colon (17,18). 2. The mechanical effect of the
          fecal stream on the stoma (19). 3. The age of the
          anastomosis (20). Adenocarcinoma of the colon mucosa is a
          recognized complication of ureterosigmoidostomy. The tumor,
          which develops adjacent to the junction of the ureter with
          the bowel, occurs 500 times as often as in the population at
          large and, in children so operated , 7,000 times as often as
          in all persons under age 25. The latency period is 5 to 50
          years (17,21-23).
          It is common knowledge that malignant tumors may disappear
          spontaneously although very infrequently (24-26). Usually it
          is accepted that this could be due at least partly to an
          immunological reaction (27,28). Renal adenocarcinoma is one
          of the cancer types in which such spontaneous regressions
          have been described most frequently (24,26).
          Urinary extracts from patients with aplastic anemia (29) and
          idiopathic thrombocytopenic purpura (30) are capable of
          stimulating megakaryocyte colony growth in culture, and when
          injected into rats could also induce thrombocytosis in
          peripheral blood and megakaryocytosis in the spleens of
          these animals. Stanley et al. (31) demonstrated that rabbits
          immunized with human urine concentrates from leukemic
          patients developed antibody which neutralized the mouse bone
          marrow colony stimulating factor in human urine and human
          serum.
          Urotherapy is suggested as a new kind of immunotherapy for
          cancer patients. Unlike the clonal immunotherapy the urine
          of the cancer patients contain the many tumor antigens which
          constitute the tumor. Oral auto-urotherapy will provide the
          intestinal lymphatic system the tumor antigens against which
          they may produce antibodies due to non-self recognition.
          These antibodies may be transpierced through the blood
          stream and attack the tumor and its cells.

          References:

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